IKA EasySyn 500 Advanced Synthesis Reactor, Reactor Volume 500 ml, RS232/USB, 0010016809

As soon as syntheses have to be run in a documented and reproducible way across several batches, a simple laboratory set-up is usually no longer sufficient. The IKA EasySyn 500 Advanced (0010016809) is the digitally networked version of the EasySyn reactor system for 500 millilitres of reaction volume: a complete set of reactor vessel, stand and stirrer that can be connected to a PC via RS232 and USB and automated with the IKA laboratory software labworldsoft 6. This makes the system particularly suitable for laboratories that want to log process parameters without gaps or run several synthesis steps one after another in an automated way, for example as part of GLP documentation. Compared with a freely assembled laboratory set-up of individual components, the complete system has the advantage that stand, reactor vessel, lid and stirrer fit together mechanically from the outset.

Reactor vessel and safety concept

As with the entire EasySyn series, a double-walled reactor vessel made of borosilicate glass 3.3 with a bottom outlet (SY 500 D) forms the core of the system. A spring-loaded valve spindle on the drain valve prevents glass breakage when opening, and the reactor lid provides four openings: an NS 29/32 centre joint for the stirrer as well as two further NS 29/32 and one NS 14/23 connection, for example for dropping funnels, reflux condensers or an external temperature sensor. The clamp, clamping ring and the FEP-coated O-ring are matched to the DN 100 flange connection of the 500 millilitre vessel. Both the borosilicate glass and the FEP-coated O-ring are resistant to a wide range of common solvents and reagents.

EUROSTAR 100 control: 100 Ncm with RS232 and USB interface

Instead of the simple EUROSTAR 60 digital of the Starter version, the Advanced model uses the EUROSTAR 100 control stirrer. It covers a speed range of 0/30 to 1,300 revolutions per minute and delivers up to 100 Ncm of torque at the stirring shaft for more viscous reaction media. In addition to the RS232 and USB interface for the PC connection, a timer, overload protection and temperature measurement are integrated directly in the stirrer, so that process parameters can also be recorded without separate sensors on the reactor. It drives the same PTFE-coated pitched-blade stirrer (R 4011 SY) as the Starter model. An integrated torque trend display also makes changes in viscosity during the reaction visible, an additional indicator alongside pure temperature measurement.

Draining set LT 5.40 for quick vessel changes

In contrast to the Starter version, the Advanced variant includes the draining set LT 5.40 in the scope of delivery. Via its own valves, the temperature control liquid can be drained cleanly and without drip losses from the double jacket of the reactor vessel, which noticeably speeds up changing between different reactor vessels or batches, a detail that pays off above all with frequently changing test series.

Vacuum operation and temperature range

A special stirrer shaft guide allows operation under vacuum down to 3 mbar, useful for degassing or for bubble-free homogenisation of reaction batches. The materials used are designed for temperatures from minus 50 to plus 200 °C, and the permissible ambient temperature for operation is 5 to 40 °C. The vessel can be used from 30 millilitres of filling volume, and with the temperature sensor immersed the minimum usable volume is 260 millilitres. As with all EasySyn models, the stirrer shaft guide (SY guide) seals the passage of the stirring shaft through the reactor lid and is what makes vacuum operation possible in the first place.

Ergonomic stand system with quick vessel change

With the Advanced version too, the stand system is ergonomically designed: the working height can be adjusted to the height of the operator, and thanks to the well-thought-out clamping mechanism the reactor vessel itself can be swiftly exchanged for another vessel of the same flange class. In combination with the draining set LT 5.40, a complete batch change, from draining the double jacket to inserting a new reactor vessel, can be carried out considerably faster than with a classic laboratory set-up of individual components.

Typical applications

The digital connection makes the EasySyn 500 Advanced particularly interesting for applications with increased documentation requirements:

• Documentation of synthesis parameters in a GLP environment via the PC connection and labworldsoft 6
• Automated, multi-step reaction control with reproducible process steps
• Development and optimisation of new synthesis routes on the 500 millilitre scale before scale-up
• Test series with frequent vessel changes thanks to the draining set LT 5.40
• Research and process development requiring gap-free process monitoring

Technical details

Scope of delivery

• 1 x SY stand
• 1 x reactor vessel SY 500 D (500 ml, borosilicate glass 3.3, with bottom outlet)
• 1 x SY clamp 100
• 1 x SY clamping ring 100
• 1 x SY O-ring 100 (FEP-coated)
• 1 x reactor lid SY 100.1
• 1 x pitched-blade stirrer R 4011 SY (PTFE-coated)
• 1 x EUROSTAR 100 control stirrer
• 1 x quick-release chuck R 60
• 1 x draining set LT 5.40
• 1 x stirrer shaft guide

Not included are temperature control hoses for connecting an external circulating thermostat, and the thermostat itself, both of which are additionally required for temperature-controlled operation of the double jacket. The automation software labworldsoft 6 is likewise not part of the scope of delivery but is available separately.

Regulatory information

The EUROSTAR 100 control stirrer is an electrical appliance within the meaning of the German Electrical and Electronic Equipment Act (ElektroG). The WEEE registration number of the manufacturer IKA is DE 66784213. Information on returning old appliances can be found on our page Environment and disposal.

Individual requirements & procurement service

For extending the EasySyn 500 Advanced, we offer further original accessories through our procurement service, for example additional reactor vessels and reactor lids, stirring tools in other designs, seal sets, suitable circulating thermostats for temperature control of the double jacket, and the automation software labworldsoft 6. We are also happy to help you put together a complete temperature control system or with spare parts. Further information and contact options can be found on our service page.

The manufacturer's warranty from IKA applies to the EUROSTAR 100 control stirrer as the drive of the system: 2 years, extended to 3 years if registered at ika.com/register within 90 days of purchase.