IKA LR 1000.1 laboratory reactor vessel, vacuum reactor vessel, 1000 ml, 0003602000

Thermodynamic process control at the demanding laboratory scale

In chemical process engineering, pharmaceutical formulation development and cosmetic synthesis, the precise scale-up of reactions is a highly critical physical challenge. The IKA LR 1000.1 laboratory reactor vessel, as a modular core component of the LR 1000 basic and control systems, is designed precisely for this task. With a usable volume of 1000 millilitres, the vessel enables the precise simulation of industrial mixing and dispersion processes. The thermodynamic design of the vessel allows for a continuous maximum operating temperature of the product of up to 120 °C. Thanks to the direct thermal coupling with the base unit’s heating element, thermal energy is transferred absolutely homogeneously into the reaction medium. This prevents localised overheating (hotspots), which could lead to the denaturation of thermolabile active pharmaceutical ingredients (APIs) or to the uncontrolled boiling of solvents.

Fluid mechanics for extremely high-viscosity media

Conventional beakers or Erlenmeyer flasks immediately reach their physical limits when processing viscous ointments, highly concentrated polymer solutions or resins. The cylindrical LR 1000.1 vessel is fluid-dynamically optimised for processing media with a dynamic viscosity of up to 100,000 mPa·s. When combined with the appropriate IKA anchor stirrers (such as the LR 1000.11) or high-performance T 25 ULTRA-TURRAX dispersers, this vessel generates immense hydrodynamic shear forces. The wall-following agitation prevents viscous product residues from adhering to the vessel walls, guarantees continuous mass transfer and ensures the physical stability of complex, multiphase emulsions and suspensions.

Hermetic isolation and absolute vacuum compatibility

A key feature for demanding syntheses is complete control over the atmosphere inside the reactor. The LR 1000.1 is designed for highly sealed operation under vacuum. This is an essential process requirement for the bubble-free degassing of viscous gels or for carrying out moisture-sensitive reactions under inert protective gases (such as argon or nitrogen). The solid reactor lid is equipped with standardised ground-joint ports (3 x NS 14 and 1 x NS 29) for this purpose. These precision-ground ports allow for the absolutely gas-tight insertion of PT 100 temperature sensors, pH electrodes, drip funnels for the precise dosing of reactants, or reflux condensers for the condensation of volatile solvents. The vacuum valve (NS 14), which is already integrated into the lid, enables the direct, controlled evacuation of the system.

Material integrity for GMP-regulated environments

To rule out cross-contamination and ensure complete chemical resistance to aggressive acids, strong alkalis and organic solvents, all components in contact with the process medium are made from materials of the highest industrial grade. The transparent reactor vessel is made from temperature-cycling-resistant borosilicate glass 3.3, which enables continuous visual monitoring of phase transitions or colour changes during the process. The metallic components, such as sensor feed-throughs and screw connections, are made from high-quality AISI 316L stainless steel, whilst PTFE and extremely durable FPM elastomers serve as sealing materials. The entire reactor vessel can be completely dismantled and cleaned thermally or chemically for decontamination in accordance with Good Laboratory Practice (GLP) standards.

Technical details

• Maximum working volume: 1000 ml
• Max. operating temperature of the product: 120 °C
• Fluid dynamics design: For viscosities up to 100,000 mPa·s (system-dependent)
• Vacuum compatibility: Designed for vacuum operation and degassing processes
• Reactor vessel material: Borosilicate glass 3.3 (highly transparent, chemically resistant)
• Material (metals in contact with the medium): AISI 316L stainless steel (material no. 1.4404)
• Seal material: FPM (fluorinated rubber) and PTFE
• Lid connections (standard ground joints): 3 x NS 14, 1 x NS 29
• Vacuum integration: Includes NS 14 vacuum tap for direct evacuation
• Compatible drive systems: IKA LR 1000 basic base and LR 1000 control base
• Permissible ambient temperature: 5 – 40 °C
• Hygiene: Can be completely dismantled for thorough cleaning

Scope of supply

• 1 x IKA LR 1000.1 laboratory reactor vessel (1000 ml, borosilicate glass)
• 1 x reactor lid with FPM seals
• 2 x NS 14 glass stoppers (including clamps)
• 1 x NS 29 glass stopper (including fixing clamp)
• 1 x NS 14 vacuum tap

(Important note: The IKA base unit, sensors and stirring and dispersing tools are not included in the scope of delivery!)

Customised requirements & accessories

The LR 1000.1 vessel is the reaction vessel itself and must be coupled with the LR 1000 basic base or control base heating unit. For mechanical drive, you will also require the appropriate IKA anchor stirrer (e.g. model LR 1000.11 in stainless steel or LR 1000.10 with PEEK scrapers for media that adhere strongly to the vessel walls). If you wish to use the vessel in conjunction with an ULTRA-TURRAX T 25 for high-shear dispersion, we would be happy to advise you on the appropriate shaft mounting. Please feel free to contact our procurement service, which specialises in process engineering, at any time for a bespoke configuration of your reactor system.